10 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Creighton | 1 | 1,096 | 1,149 | -0.81% | 906 | 1 | City |
| Bloomfield | 2 | 918 | 983 | -1.18% | 1,125 | 1 | City |
| Crofton | 3 | 759 | 755 | 0.13% | 1,186 | 1 | City |
| Wausa | 4 | 577 | 591 | -0.35% | 1,101 | 1 | Village |
| Verdigre | 5 | 528 | 545 | -0.56% | 964 | 1 | Village |
| Santee | 6 | 429 | 423 | 0.23% | 761 | 1 | Village |
| Niobrara | 7 | 359 | 365 | -0.28% | 493 | 1 | Village |
| Center | 8 | 69 | 74 | -1.43% | 657 | 0 | Village |
| Winnetoon | 9 | 53 | 53 | 0% | 183 | 0 | Village |
| Verdel | 10 | 41 | 40 | 0% | 237 | 0 | Village |
Creighton is the largest city in Knox County, with a population of 1,096.
Verdel is the smallest city in Knox County, with a population of 41.
There are 10 cities in Knox County, Nebraska.