| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Creighton | 1 | 1,107 | 1,149 | -0.54% | 915 | 1 | City |
| Bloomfield | 2 | 933 | 984 | -0.85% | 1,143 | 1 | City |
| Crofton | 3 | 763 | 752 | 0.26% | 1,192 | 1 | City |
| Wausa | 4 | 578 | 587 | -0.17% | 1,103 | 1 | Village |
| Verdigre | 5 | 530 | 546 | -0.38% | 967 | 1 | Village |
| Santee | 6 | 431 | 422 | 0.47% | 764 | 1 | Village |
| Niobrara | 7 | 362 | 365 | 0% | 497 | 1 | Village |
| Center | 8 | 70 | 73 | -1.41% | 667 | 0 | Village |
| Winnetoon | 9 | 53 | 53 | 0% | 183 | 0 | Village |
| Verdel | 10 | 41 | 40 | 0% | 237 | 0 | Village |
Creighton is the largest city in Knox County, with a population of 1,107.
Verdel is the smallest city in Knox County, with a population of 41.
There are 10 cities in Knox County, Nebraska.