| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Plattsmouth | 1 | 7,028 | 6,593 | 1.05% | 2,119 | 3 | City |
| Louisville | 2 | 1,434 | 1,348 | 1.06% | 2,153 | 1 | City |
| Eagle | 3 | 1,235 | 1,091 | 2.4% | 2,906 | 0 | Village |
| Weeping Water | 4 | 1,066 | 1,037 | 0.47% | 1,018 | 1 | City |
| Elmwood | 5 | 687 | 668 | 0.44% | 1,523 | 0 | Village |
| Greenwood | 6 | 620 | 596 | 0.65% | 1,509 | 0 | Village |
| Murray | 7 | 505 | 487 | 0.6% | 1,443 | 0 | Village |
| Cedar Creek | 8 | 478 | 464 | 0.42% | 912 | 1 | Village |
| Murdock | 9 | 277 | 269 | 0.36% | 2,022 | 0 | Village |
| Union | 10 | 200 | 195 | 0% | 1,058 | 0 | Village |
| Avoca | 11 | 187 | 182 | 0% | 1,326 | 0 | Village |
| Nehawka | 12 | 179 | 174 | 0.56% | 731 | 0 | Village |
| Manley | 13 | 174 | 169 | 0% | 1,513 | 0 | Village |
| Alvo | 14 | 125 | 122 | 0% | 912 | 0 | Village |
| South Bend | 15 | 95 | 90 | 1.06% | 1,284 | 0 | Village |
Plattsmouth is the largest city in Cass County, with a population of 7,028.
South Bend is the smallest city in Cass County, with a population of 95.
There are 15 cities in Cass County, Nebraska.