42 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Buffalo | 1 | 276,381 | 277,558 | -0.09% | 6,845 | 40 | City |
| Amherst | 2 | 130,981 | 129,359 | 0.09% | 2,462 | 53 | Town |
| Cheektowaga | 3 | 88,488 | 89,748 | 0% | 3,005 | 29 | Town |
| Tonawanda | 4 | 71,393 | 72,444 | -0.03% | 3,811 | 19 | Town |
| Hamburg | 5 | 61,097 | 60,052 | 0.8% | 1,479 | 41 | Town |
| West Seneca | 6 | 45,586 | 45,470 | 0.45% | 2,131 | 21 | Town |
| Lancaster | 7 | 45,466 | 45,039 | 0.36% | 1,206 | 38 | Town |
| Clarence | 8 | 33,359 | 32,948 | 0.28% | 623 | 54 | Town |
| Orchard Park | 9 | 29,970 | 29,668 | 0.28% | 780 | 38 | Town |
| Grand Island | 10 | 21,651 | 21,448 | 0.4% | 766 | 28 | Town |
| Lackawanna | 11 | 19,553 | 19,931 | -0.39% | 2,986 | 7 | City |
| Evans | 12 | 15,131 | 15,295 | -0.01% | 364 | 42 | Town |
| Tonawanda | 13 | 14,948 | 15,125 | -0.24% | 3,931 | 4 | City |
| Kenmore | 14 | 14,876 | 15,174 | -0.4% | 10,359 | 1 | Village |
| Depew | 15 | 14,850 | 15,149 | -0.4% | 2,926 | 5 | Village |
| Elma | 16 | 11,735 | 11,711 | 0.3% | 340 | 35 | Town |
| Alden | 17 | 10,483 | 9,673 | 2.79% | 305 | 34 | Town |
| Lancaster | 18 | 10,075 | 10,170 | -0.19% | 3,707 | 3 | Village |
| Hamburg | 19 | 9,856 | 9,750 | 0.21% | 3,976 | 2 | Village |
| Newstead | 20 | 8,719 | 8,690 | 0.31% | 172 | 51 | Town |
| Concord | 21 | 8,302 | 8,304 | 0.47% | 119 | 70 | Town |
| Boston | 22 | 7,956 | 7,948 | 0.1% | 222 | 36 | Town |
| Eden | 23 | 7,571 | 7,567 | 0.32% | 190 | 40 | Town |
| East Aurora | 24 | 5,989 | 5,972 | 0.05% | 2,385 | 3 | Village |
| Williamsville | 25 | 5,508 | 5,411 | 0.35% | 4,378 | 1 | Village |
| Marilla | 26 | 5,144 | 5,176 | -0.02% | 187 | 28 | Town |
| Collins | 27 | 4,509 | 5,672 | 4.18% | 94 | 48 | Town |
| Springville | 28 | 4,189 | 4,212 | -0.12% | 1,138 | 4 | Village |
| Sloan | 29 | 3,720 | 3,770 | -0.27% | 4,769 | 1 | Village |
| North Collins | 30 | 3,519 | 3,500 | 0.17% | 82 | 43 | Town |
| Holland | 31 | 3,260 | 3,275 | 0.09% | 91 | 36 | Town |
| Colden | 32 | 3,198 | 3,123 | 0.66% | 90 | 36 | Town |
| Wales | 33 | 3,035 | 3,009 | 0.5% | 85 | 36 | Town |
| Orchard Park | 34 | 3,034 | 3,091 | -0.39% | 1,656 | 2 | Village |
| Akron | 35 | 2,880 | 2,909 | -0.21% | 1,431 | 2 | Village |
| Alden | 36 | 2,804 | 2,602 | 1.45% | 1,032 | 3 | Village |
| Sardinia | 37 | 2,709 | 2,712 | 0.22% | 54 | 50 | Town |
| Blasdell | 38 | 2,563 | 2,533 | 0.23% | 2,280 | 1 | Village |
| Angola | 39 | 2,020 | 2,048 | -0.3% | 1,426 | 1 | Village |
| Brant | 40 | 1,935 | 1,913 | 0.21% | 80 | 24 | Town |
| North Collins | 41 | 1,271 | 1,261 | 0.16% | 1,587 | 1 | Village |
| Farnham | 42 | 362 | 365 | -0.28% | 300 | 1 | Village |
Buffalo is the largest city in Erie County, with a population of 276,381.
Farnham is the smallest city in Erie County, with a population of 362.
There are 42 cities in Erie County, New York.