| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Buffalo | 1 | 274,006 | 277,750 | -0.22% | 6,786 | 40 | City |
| Amherst | 2 | 130,132 | 129,343 | -0.24% | 2,446 | 53 | Town |
| Cheektowaga | 3 | 88,117 | 89,712 | -0.05% | 2,992 | 29 | Town |
| Tonawanda | 4 | 70,595 | 72,454 | -0.36% | 3,768 | 19 | Town |
| Hamburg | 5 | 61,104 | 60,055 | 0.55% | 1,479 | 41 | Town |
| West Seneca | 6 | 45,696 | 45,509 | 0.5% | 2,137 | 21 | Town |
| Lancaster | 7 | 45,025 | 45,030 | -0.11% | 1,194 | 38 | Town |
| Clarence | 8 | 33,229 | 32,947 | 0.09% | 621 | 54 | Town |
| Orchard Park | 9 | 29,827 | 29,670 | 0.08% | 776 | 38 | Town |
| Grand Island | 10 | 21,686 | 21,444 | 0.46% | 767 | 28 | Town |
| Lackawanna | 11 | 19,357 | 19,899 | -0.49% | 2,956 | 7 | City |
| Evans | 12 | 15,004 | 15,298 | -0.24% | 361 | 42 | Town |
| Tonawanda | 13 | 14,793 | 15,122 | -0.37% | 3,890 | 4 | City |
| Kenmore | 14 | 14,730 | 15,176 | -0.53% | 10,258 | 1 | Village |
| Depew | 15 | 14,728 | 15,147 | -0.49% | 2,901 | 5 | Village |
| Elma | 16 | 11,679 | 11,709 | 0.1% | 338 | 35 | Town |
| Alden | 17 | 10,349 | 9,674 | 0.85% | 302 | 34 | Town |
| Lancaster | 18 | 9,963 | 10,157 | -0.32% | 3,666 | 3 | Village |
| Hamburg | 19 | 9,850 | 9,745 | 0.1% | 3,973 | 2 | Village |
| Newstead | 20 | 8,702 | 8,690 | 0.08% | 171 | 51 | Town |
| Concord | 21 | 8,311 | 8,331 | 0.25% | 119 | 70 | Town |
| Boston | 22 | 7,858 | 7,934 | -0.27% | 219 | 36 | Town |
| Eden | 23 | 7,514 | 7,565 | 0.01% | 189 | 40 | Town |
| East Aurora | 24 | 5,946 | 5,971 | -0.05% | 2,368 | 3 | Village |
| Williamsville | 25 | 5,491 | 5,398 | 0.24% | 4,365 | 1 | Village |
| Marilla | 26 | 5,103 | 5,178 | -0.31% | 185 | 28 | Town |
| Collins | 27 | 4,200 | 5,666 | -6.69% | 88 | 48 | Town |
| Springville | 28 | 4,186 | 4,213 | -0.19% | 1,138 | 4 | Village |
| Sloan | 29 | 3,685 | 3,768 | -0.38% | 4,724 | 1 | Village |
| North Collins | 30 | 3,468 | 3,488 | -0.26% | 81 | 43 | Town |
| Holland | 31 | 3,253 | 3,276 | -0.03% | 91 | 36 | Town |
| Colden | 32 | 3,187 | 3,112 | 0.47% | 89 | 36 | Town |
| Orchard Park | 33 | 3,064 | 3,148 | -0.49% | 1,672 | 2 | Village |
| Wales | 34 | 3,033 | 3,007 | 0.46% | 85 | 36 | Town |
| Akron | 35 | 2,859 | 2,907 | -0.28% | 1,421 | 2 | Village |
| Alden | 36 | 2,794 | 2,604 | 1.42% | 1,028 | 3 | Village |
| Sardinia | 37 | 2,686 | 2,709 | -0.07% | 53 | 50 | Town |
| Blasdell | 38 | 2,564 | 2,539 | 0.08% | 2,281 | 1 | Village |
| Angola | 39 | 2,021 | 2,051 | -0.39% | 1,426 | 1 | Village |
| Brant | 40 | 1,919 | 1,923 | -0.31% | 79 | 24 | Town |
| North Collins | 41 | 1,252 | 1,252 | 0% | 1,563 | 1 | Village |
| Farnham | 42 | 358 | 366 | -0.28% | 297 | 1 | Village |
Buffalo is the largest city in Erie County, with a population of 274,006.
Farnham is the smallest city in Erie County, with a population of 358.
There are 42 cities in Erie County, New York.