Depew
- County:
- Erie County
- County Seat:
- No
- Area (mi²):
- 5.076
- State:
- New York
Depew is a village located in Erie County, New York. Depew has a 2026 population of 14,910. Depew is currently declining at a rate of -0.01% annually and its population has decreased by -1.58% since the most recent census, which recorded a population of 15,149 in 2020.