14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Portsmouth | 1 | 17,119 | 18,209 | -1.26% | 1,596 | 10.73 | City |
| Wheelersburg | 2 | 6,160 | 6,129 | -0.29% | 1,061 | 5.80 | CDP |
| West Portsmouth | 3 | 2,388 | 2,646 | -2.05% | 508 | 4.71 | CDP |
| New Boston | 4 | 2,185 | 2,295 | -1% | 1,947 | 1.12 | Village |
| Rosemount | 5 | 1,988 | 2,292 | -0.4% | 346 | 5.75 | CDP |
| Franklin Furnace | 6 | 1,955 | 1,795 | 1.03% | 830 | 2.35 | CDP |
| Lucasville | 7 | 1,622 | 2,030 | -4.48% | 467 | 3.47 | CDP |
| Sciotodale | 8 | 747 | 714 | -2.99% | 387 | 1.93 | CDP |
| South Webster | 9 | 641 | 668 | -0.77% | 489 | 1.31 | Village |
| Friendship | 10 | 634 | 523 | 3.09% | 541 | 1.17 | CDP |
| Minford | 11 | 564 | 378 | -1.57% | 324 | 1.74 | CDP |
| McDermott | 12 | 553 | 354 | 1.47% | 955 | 0.58 | CDP |
| Rarden | 13 | 137 | 147 | -1.44% | 646 | 0.21 | Village |
| Otway | 14 | 88 | 93 | -1.12% | 503 | 0.17 | Village |
Portsmouth is the largest city in Scioto County, with a population of 17,119.
Otway is the smallest city in Scioto County.
There are 14 cities in Scioto County, Ohio.