26 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Portsmouth | 1 | 17,119 | 18,209 | -1.26% | 1,596 | 10.73 | City |
| Porter township | 2 | 9,417 | 9,782 | -0.61% | 455 | 20.69 | Township |
| Wheelersburg | 3 | 6,160 | 6,129 | -0.29% | 1,061 | 5.80 | CDP |
| Washington township | 4 | 5,068 | 5,270 | -0.65% | 203 | 24.94 | Township |
| Valley township | 5 | 3,715 | 3,595 | 2.17% | 150 | 24.70 | Township |
| Clay township | 6 | 3,398 | 3,515 | -0.59% | 157 | 21.63 | Township |
| Rush township | 7 | 2,797 | 2,886 | -0.46% | 119 | 23.43 | Township |
| Bloom township | 8 | 2,625 | 2,701 | -0.38% | 54 | 48.62 | Township |
| West Portsmouth | 9 | 2,388 | 2,646 | -2.05% | 508 | 4.71 | CDP |
| Nile township | 10 | 2,277 | 2,348 | -0.48% | 27 | 85.78 | Township |
| Morgan township | 11 | 2,222 | 2,276 | -0.31% | 75 | 29.59 | Township |
| New Boston | 12 | 2,185 | 2,295 | -1% | 1,947 | 1.12 | Village |
| Union township | 13 | 2,000 | 2,046 | -0.25% | 40 | 49.94 | Township |
| Rosemount | 14 | 1,988 | 2,292 | -0.4% | 346 | 5.75 | CDP |
| Franklin Furnace | 15 | 1,955 | 1,795 | 1.03% | 830 | 2.35 | CDP |
| Vernon township | 16 | 1,883 | 1,936 | -0.42% | 54 | 35.16 | Township |
| Lucasville | 17 | 1,622 | 2,030 | -4.48% | 467 | 3.47 | CDP |
| Brush Creek township | 18 | 1,059 | 1,092 | -0.47% | 21 | 50.48 | Township |
| Rarden township | 19 | 1,029 | 1,064 | -0.58% | 32 | 31.72 | Township |
| Sciotodale | 20 | 747 | 714 | -2.99% | 387 | 1.93 | CDP |
| South Webster | 21 | 641 | 668 | -0.77% | 489 | 1.31 | Village |
| Friendship | 22 | 634 | 523 | 3.09% | 541 | 1.17 | CDP |
| Minford | 23 | 564 | 378 | -1.57% | 324 | 1.74 | CDP |
| McDermott | 24 | 553 | 354 | 1.47% | 955 | 0.58 | CDP |
| Rarden | 25 | 137 | 147 | -1.44% | 646 | 0.21 | Village |
| Otway | 26 | 88 | 93 | -1.12% | 503 | 0.17 | Village |
Portsmouth is the largest city in Scioto County, with a population of 17,119.
Otway is the smallest city in Scioto County.
There are 26 cities in Scioto County, Ohio.