| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Portsmouth | 1 | 17,099 | 18,185 | -1.06% | 1,594 | 11 | City |
| New Boston | 2 | 2,187 | 2,296 | -0.86% | 1,949 | 1 | Village |
| South Webster | 3 | 630 | 653 | -0.79% | 480 | 1 | Village |
| Rarden | 4 | 137 | 143 | -0.72% | 646 | 0 | Village |
| Otway | 5 | 87 | 93 | -1.14% | 497 | 0 | Village |
Portsmouth is the largest city in Scioto County, with a population of 17,099.
Otway is the smallest city in Scioto County, with a population of 87.
There are 5 cities in Scioto County, Ohio.