| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Defiance | 1 | 17,003 | 17,057 | -0.04% | 1,330 | 13 | City |
| Hicksville | 2 | 3,425 | 3,425 | -0.06% | 1,341 | 3 | Village |
| Sherwood | 3 | 819 | 802 | 0.37% | 526 | 2 | Village |
| Ney | 4 | 296 | 301 | -0.34% | 755 | 0 | Village |
| Florida | 5 | 216 | 221 | -0.46% | 960 | 0 | Village |
Defiance is the largest city in Defiance County, with a population of 17,003.
Florida is the smallest city in Defiance County, with a population of 216.
There are 5 cities in Defiance County, Ohio.