Defiance
- County:
- Defiance County
- County Seat:
- Yes
- Area (mi²):
- 12.786
- State:
- Ohio
Defiance is a city located in Defiance County, Ohio. Defiance has a 2026 population of 17,180. It is also the county seat of Defiance County. Defiance is currently growing at a rate of 0.53% annually and its population has increased by 0.76% since the most recent census, which recorded a population of 17,050 in 2020.