| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Cambridge | 1 | 10,038 | 10,116 | -0.17% | 1,576 | 6 | City |
| Byesville | 2 | 2,356 | 2,368 | -0.13% | 1,967 | 1 | Village |
| Senecaville | 3 | 406 | 410 | -0.25% | 855 | 0 | Village |
| Pleasant City | 4 | 395 | 399 | -0.25% | 2,244 | 0 | Village |
| Quaker City | 5 | 374 | 380 | -0.27% | 711 | 1 | Village |
| Cumberland | 6 | 313 | 316 | -0.32% | 644 | 0 | Village |
| Lore City | 7 | 279 | 283 | -0.36% | 851 | 0 | Village |
| Old Washington | 8 | 226 | 229 | -0.44% | 336 | 1 | Village |
| Batesville | 9 | 101 | 101 | -0.98% | 447 | 0 | Village |
| Fairview | 10 | 67 | 68 | -1.47% | 167 | 0 | Village |
Cambridge is the largest city in Guernsey County, with a population of 10,038.
Fairview is the smallest city in Guernsey County, with a population of 67.
There are 10 cities in Guernsey County, Ohio.