10 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Cambridge | 1 | 9,998 | 10,111 | -0.19% | 1,570 | 6 | City |
| Byesville | 2 | 2,338 | 2,364 | -0.17% | 1,952 | 1 | Village |
| Senecaville | 3 | 412 | 418 | -0.24% | 867 | 0 | Village |
| Pleasant City | 4 | 387 | 396 | -0.26% | 2,199 | 0 | Village |
| Quaker City | 5 | 372 | 380 | -0.27% | 707 | 1 | Village |
| Cumberland | 6 | 312 | 317 | -0.32% | 642 | 0 | Village |
| Lore City | 7 | 275 | 283 | -0.36% | 838 | 0 | Village |
| Old Washington | 8 | 221 | 224 | 0% | 329 | 1 | Village |
| Batesville | 9 | 98 | 101 | 0% | 434 | 0 | Village |
| Fairview | 10 | 68 | 70 | 0% | 170 | 0 | Village |
Cambridge is the largest city in Guernsey County, with a population of 9,998.
Fairview is the smallest city in Guernsey County, with a population of 68.
There are 10 cities in Guernsey County, Ohio.