12 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Helena | 1 | 1,532 | 1,536 | -0.07% | 3,755 | 0.41 | Town |
| Cherokee | 2 | 1,430 | 1,469 | -0.56% | 700 | 2.04 | City |
| Carmen | 3 | 353 | 358 | -0.28% | 232 | 1.52 | Town |
| Goltry | 4 | 250 | 254 | -0.4% | 625 | 0.40 | Town |
| Jet | 5 | 193 | 197 | -0.52% | 710 | 0.27 | Town |
| Aline | 6 | 169 | 169 | 0% | 638 | 0.27 | Town |
| Nescatunga | 7 | 161 | 69 | 7.33% | 712 | 0.23 | CDP |
| Burlington | 8 | 125 | 125 | 0% | 458 | 0.27 | Town |
| Amorita | 9 | 39 | 39 | 0% | 154 | 0.25 | Town |
| Byron | 10 | 36 | 36 | 0% | 143 | 0.25 | Town |
| Avard | 11 | 16 | 38 | 6.67% | 152 | 0.10 | CDP |
| Lambert | 12 | 6 | 6 | 0% | 54 | 0.11 | Town |
Helena is the largest city in Alfalfa County, with a population of 1,532.
Lambert is the smallest city in Alfalfa County.
There are 12 cities in Alfalfa County, Oklahoma.