| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Helena | 1 | 1,527 | 1,532 | 0% | 3,743 | 0 | Town |
| Cherokee | 2 | 1,437 | 1,471 | -0.14% | 704 | 2 | City |
| Carmen | 3 | 353 | 361 | -0.28% | 232 | 2 | Town |
| Goltry | 4 | 248 | 251 | 0% | 620 | 0 | Town |
| Jet | 5 | 193 | 196 | 0% | 710 | 0 | Town |
| Aline | 6 | 168 | 170 | 0% | 634 | 0 | Town |
| Burlington | 7 | 118 | 120 | 0% | 432 | 0 | Town |
| Amorita | 8 | 39 | 39 | 0% | 154 | 0 | Town |
| Byron | 9 | 39 | 40 | 0% | 155 | 0 | Town |
| Lambert | 10 | 6 | 6 | 0% | 54 | 0 | Town |
Helena is the largest city in Alfalfa County, with a population of 1,527.
Lambert is the smallest city in Alfalfa County, with a population of 6.
There are 10 cities in Alfalfa County, Oklahoma.