| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Lawton | 1 | 90,468 | 90,377 | -0.04% | 1,108 | 82 | City |
| Elgin | 2 | 3,671 | 3,564 | 0.49% | 983 | 4 | City |
| Cache | 3 | 3,297 | 2,943 | 1.79% | 905 | 4 | City |
| Fletcher | 4 | 1,283 | 1,211 | 0.71% | 667 | 2 | Town |
| Central High | 5 | 1,241 | 1,172 | 0.98% | 23 | 53 | Town |
| Geronimo | 6 | 1,189 | 1,159 | 0.08% | 797 | 1 | Town |
| Bray | 7 | 998 | 942 | 1.01% | 16 | 62 | Town |
| Sterling | 8 | 673 | 675 | -0.15% | 819 | 1 | Town |
| Medicine Park | 9 | 513 | 412 | 3.22% | 232 | 2 | Town |
| Chattanooga | 10 | 410 | 406 | 0% | 782 | 1 | Town |
| Indiahoma | 11 | 276 | 277 | 0% | 993 | 0 | Town |
| Faxon | 12 | 117 | 115 | 0% | 455 | 0 | Town |
Lawton is the largest city in Comanche County, with a population of 90,468.
Faxon is the smallest city in Comanche County, with a population of 117.
There are 12 cities in Comanche County, Oklahoma.