| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Medford | 1 | 896 | 935 | -0.55% | 577 | 2 | City |
| Pond Creek | 2 | 877 | 895 | -0.11% | 1,033 | 1 | City |
| Wakita | 3 | 302 | 314 | -0.66% | 971 | 0 | Town |
| Lamont | 4 | 291 | 304 | -0.68% | 858 | 0 | Town |
| Nash | 5 | 182 | 188 | -0.55% | 548 | 0 | Town |
| Manchester | 6 | 92 | 91 | 0% | 380 | 0 | Town |
| Deer Creek | 7 | 77 | 80 | -1.28% | 542 | 0 | Town |
| Renfrow | 8 | 20 | 21 | 0% | 208 | 0 | Town |
| Jefferson | 9 | 11 | 11 | 0% | 40 | 0 | Town |
Medford is the largest city in Grant County, with a population of 896.
Jefferson is the smallest city in Grant County, with a population of 11.
There are 9 cities in Grant County, Oklahoma.