18 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Medford | 1 | 910 | 932 | -0.55% | 750 | 1 | City |
| Medford | 2 | 910 | 933 | -0.55% | 750 | 1 | City |
| Pond Creek | 3 | 892 | 890 | -0.11% | 1,051 | 1 | City |
| Pond Creek | 4 | 892 | 895 | -0.11% | 1,051 | 1 | City |
| Wakita | 5 | 306 | 313 | -0.65% | 984 | 0 | Town |
| Wakita | 6 | 306 | 314 | -0.65% | 984 | 0 | Town |
| Lamont | 7 | 291 | 298 | -0.68% | 858 | 0 | Town |
| Lamont | 8 | 291 | 299 | -0.68% | 858 | 0 | Town |
| Nash | 9 | 186 | 189 | -0.53% | 560 | 0 | Town |
| Nash | 10 | 186 | 189 | -0.53% | 560 | 0 | Town |
| Manchester | 11 | 90 | 89 | 0% | 372 | 0 | Town |
| Manchester | 12 | 90 | 89 | 0% | 372 | 0 | Town |
| Deer Creek | 13 | 74 | 76 | -1.33% | 521 | 0 | Town |
| Deer Creek | 14 | 74 | 76 | -1.33% | 521 | 0 | Town |
| Renfrow | 15 | 18 | 18 | 0% | 188 | 0 | Town |
| Renfrow | 16 | 18 | 18 | 0% | 188 | 0 | Town |
| Jefferson | 17 | 10 | 10 | 0% | 37 | 0 | Town |
| Jefferson | 18 | 10 | 10 | 0% | 37 | 0 | Town |
Medford is the largest city in Grant County, with a population of 910.
Jefferson is the smallest city in Grant County, with a population of 10.
There are 18 cities in Grant County, Oklahoma.