16 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Altus | 1 | 18,502 | 18,738 | -0.22% | 1,016 | 18 | City |
| Altus | 2 | 18,502 | 18,704 | -0.22% | 1,016 | 18 | City |
| Blair | 3 | 707 | 721 | -0.42% | 1,482 | 0 | Town |
| Blair | 4 | 707 | 720 | -0.42% | 1,482 | 0 | Town |
| Olustee | 5 | 457 | 466 | -0.44% | 549 | 1 | Town |
| Olustee | 6 | 457 | 465 | -0.44% | 549 | 1 | Town |
| Eldorado | 7 | 313 | 321 | -0.63% | 426 | 1 | Town |
| Eldorado | 8 | 313 | 320 | -0.63% | 426 | 1 | Town |
| Martha | 9 | 158 | 162 | -0.63% | 627 | 0 | Town |
| Martha | 10 | 158 | 162 | -0.63% | 627 | 0 | Town |
| Headrick | 11 | 72 | 74 | -1.37% | 326 | 0 | Town |
| Headrick | 12 | 72 | 74 | -1.37% | 326 | 0 | Town |
| Elmer | 13 | 62 | 64 | -1.59% | 147 | 0 | Town |
| Elmer | 14 | 62 | 64 | -1.59% | 147 | 0 | Town |
| Friendship | 15 | 22 | 24 | -4.35% | 147 | 0 | Town |
| Friendship | 16 | 22 | 24 | -4.35% | 147 | 0 | Town |
Altus is the largest city in Jackson County, with a population of 18,502.
Friendship is the smallest city in Jackson County, with a population of 22.
There are 16 cities in Jackson County, Oklahoma.