12 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Shawnee | 1 | 32,287 | 31,311 | 0.61% | 836 | 39 | City |
| Tecumseh | 2 | 6,385 | 6,310 | 0.24% | 425 | 15 | City |
| McLoud | 3 | 4,558 | 4,360 | 0.86% | 253 | 18 | City |
| Bethel Acres | 4 | 3,326 | 3,045 | 1.71% | 118 | 28 | Town |
| Maud | 5 | 869 | 863 | 0.12% | 828 | 1 | City |
| Earlsboro | 6 | 615 | 595 | 0.65% | 66 | 9 | Town |
| Johnson | 7 | 471 | 458 | 0.43% | 105 | 4 | Town |
| Asher | 8 | 377 | 370 | 0.27% | 491 | 1 | Town |
| Wanette | 9 | 312 | 306 | 0.32% | 768 | 0 | Town |
| St. Louis | 10 | 127 | 126 | 0% | 13 | 9 | Town |
| Brooksville | 11 | 74 | 73 | 0% | 25 | 3 | Town |
| Macomb | 12 | 22 | 22 | 0% | 247 | 0 | Town |
Shawnee is the largest city in Pottawatomie County, with a population of 32,287.
Macomb is the smallest city in Pottawatomie County, with a population of 22.
There are 12 cities in Pottawatomie County, Oklahoma.