16 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Guymon | 1 | 12,271 | 12,959 | -1.02% | 1,586 | 8 | City |
| Guymon | 2 | 12,271 | 12,899 | -1.02% | 1,586 | 8 | City |
| Hooker | 3 | 1,716 | 1,802 | -0.92% | 1,552 | 1 | City |
| Hooker | 4 | 1,716 | 1,795 | -0.92% | 1,552 | 1 | City |
| Goodwell | 5 | 921 | 954 | -0.65% | 419 | 2 | Town |
| Goodwell | 6 | 921 | 951 | -0.65% | 419 | 2 | Town |
| Texhoma | 7 | 828 | 864 | -0.84% | 1,292 | 1 | Town |
| Texhoma | 8 | 828 | 860 | -0.84% | 1,292 | 1 | Town |
| Tyrone | 9 | 736 | 732 | 0.14% | 1,744 | 0 | Town |
| Tyrone | 10 | 736 | 729 | 0.14% | 1,744 | 0 | Town |
| Optima | 11 | 324 | 338 | -0.92% | 608 | 1 | Town |
| Optima | 12 | 324 | 337 | -0.92% | 608 | 1 | Town |
| Adams | 13 | 311 | 306 | 7.24% | 616 | 1 | CDP |
| Hardesty | 14 | 200 | 205 | -0.5% | 889 | 0 | Town |
| Hardesty | 15 | 200 | 204 | -0.5% | 889 | 0 | Town |
| Hough | 16 | 35 | 12 | 6.06% | 507 | 0 | CDP |
Guymon is the largest city in Texas County, with a population of 12,271.
Hough is the smallest city in Texas County, with a population of 35.
There are 16 cities in Texas County, Oklahoma.