14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bluffton | 1 | 39,846 | 28,338 | 6.13% | 764 | 52.13 | Town |
| Hilton Head Island | 2 | 38,437 | 37,587 | 0.44% | 929 | 41.35 | Town |
| Port Royal | 3 | 17,476 | 14,503 | 3.52% | 1,030 | 16.96 | Town |
| Beaufort | 4 | 14,020 | 13,594 | 0.61% | 574 | 24.43 | City |
| Burton | 5 | 7,760 | 8,779 | 0.68% | 929 | 8.35 | CDP |
| Laurel Bay | 6 | 5,418 | 6,388 | -0.59% | 1,301 | 4.16 | CDP |
| Shell Point | 7 | 1,949 | 2,991 | -1.27% | 486 | 4.01 | CDP |
| Seabrook | 8 | 1,359 | 1,456 | 7.18% | 247 | 5.50 | CDP |
| Dale | 9 | 1,196 | 699 | 7.17% | 504 | 2.37 | CDP |
| Fripp Island | 10 | 959 | 848 | 7.15% | 294 | 3.26 | CDP |
| Daufuskie Island | 11 | 711 | 485 | 7.08% | 72 | 9.81 | CDP |
| Sheldon | 12 | 549 | 501 | 7.23% | 126 | 4.36 | CDP |
| Harbor Island | 13 | 346 | 316 | 7.12% | 337 | 1.03 | CDP |
| Lobeco | 14 | 245 | 349 | 6.99% | 93 | 2.63 | CDP |
Bluffton is the largest city in Beaufort County, with a population of 39,846.
Lobeco is the smallest city in Beaufort County.
There are 14 cities in Beaufort County, South Carolina.