8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Wyboo | 1 | 4,732 | 4,027 | 7.13% | 316 | 15 | CDP |
| Manning | 2 | 3,813 | 3,905 | -0.5% | 1,299 | 3 | City |
| Summerton | 3 | 774 | 809 | -0.9% | 572 | 1 | Town |
| Turbeville | 4 | 738 | 760 | -0.67% | 551 | 1 | Town |
| North Santee | 5 | 588 | 719 | 7.3% | 65 | 9 | CDP |
| Alcolu | 6 | 374 | 413 | -1.06% | 82 | 5 | CDP |
| Paxville | 7 | 224 | 227 | -0.44% | 213 | 1 | Town |
| Foreston | 8 | 166 | 124 | 7.1% | 73 | 2 | CDP |
Wyboo is the largest city in Clarendon County, with a population of 4,732.
Foreston is the smallest city in Clarendon County, with a population of 166.
There are 8 cities in Clarendon County, South Carolina.