8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Wyboo | 1 | 4,732 | 4,027 | 7.13% | 316 | 14.96 | CDP |
| Manning | 2 | 3,762 | 3,862 | -0.53% | 1,282 | 2.94 | City |
| Summerton | 3 | 774 | 811 | -0.9% | 572 | 1.35 | Town |
| Turbeville | 4 | 736 | 761 | -0.68% | 549 | 1.34 | Town |
| North Santee | 5 | 588 | 719 | 7.3% | 65 | 9.11 | CDP |
| Alcolu | 6 | 374 | 413 | -1.06% | 82 | 4.55 | CDP |
| Paxville | 7 | 227 | 231 | -0.44% | 216 | 1.05 | Town |
| Foreston | 8 | 166 | 124 | 7.1% | 73 | 2.28 | CDP |
Wyboo is the largest city in Clarendon County, with a population of 4,732.
Foreston is the smallest city in Clarendon County.
There are 8 cities in Clarendon County, South Carolina.