| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Manning | 1 | 3,814 | 3,904 | -0.39% | 1,299 | 3 | City |
| Summerton | 2 | 769 | 808 | -0.9% | 568 | 1 | Town |
| Turbeville | 3 | 748 | 762 | -0.4% | 558 | 1 | Town |
| Paxville | 4 | 227 | 230 | -0.44% | 216 | 1 | Town |
Manning is the largest city in Clarendon County, with a population of 3,814.
Paxville is the smallest city in Clarendon County, with a population of 227.
There are 4 cities in Clarendon County, South Carolina.