| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Walterboro | 1 | 5,488 | 5,495 | 0.05% | 773 | 7 | City |
| Cottageville | 2 | 741 | 710 | 0.82% | 217 | 3 | Town |
| Smoaks | 3 | 97 | 98 | 0% | 60 | 2 | Town |
| Williams | 4 | 95 | 96 | 0% | 112 | 1 | Town |
| Lodge | 5 | 85 | 85 | 0% | 27 | 3 | Town |
Walterboro is the largest city in Colleton County, with a population of 5,488.
Lodge is the smallest city in Colleton County, with a population of 85.
There are 5 cities in Colleton County, South Carolina.