5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Seneca | 1 | 9,373 | 8,860 | 0.93% | 1,107 | 8 | City |
| Walhalla | 2 | 4,334 | 4,079 | 1% | 1,116 | 4 | City |
| Westminster | 3 | 2,481 | 2,354 | 0.85% | 720 | 3 | City |
| West Union | 4 | 396 | 375 | 1.02% | 499 | 1 | Town |
| Salem | 5 | 131 | 119 | 1.55% | 143 | 1 | Town |
Seneca is the largest city in Oconee County, with a population of 9,373.
Salem is the smallest city in Oconee County, with a population of 131.
There are 5 cities in Oconee County, South Carolina.