| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Seneca | 1 | 9,515 | 8,851 | 0.97% | 1,124 | 8 | City |
| Walhalla | 2 | 4,366 | 4,084 | 1.06% | 1,124 | 4 | City |
| Westminster | 3 | 2,528 | 2,375 | 0.96% | 734 | 3 | City |
| West Union | 4 | 399 | 371 | 1.01% | 503 | 1 | Town |
| Salem | 5 | 130 | 119 | 0.78% | 142 | 1 | Town |
Seneca is the largest city in Oconee County, with a population of 9,515.
Salem is the smallest city in Oconee County, with a population of 130.
There are 5 cities in Oconee County, South Carolina.