| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Easley | 1 | 28,302 | 23,040 | 3.6% | 2,183 | 13 | City |
| Clemson | 2 | 19,149 | 17,758 | 1.1% | 2,421 | 8 | City |
| Central | 3 | 5,309 | 5,298 | 0.21% | 976 | 5 | Town |
| Liberty | 4 | 3,336 | 3,391 | -0.24% | 677 | 5 | City |
| Pickens | 5 | 3,194 | 3,145 | 0.19% | 1,044 | 3 | City |
| Six Mile | 6 | 771 | 759 | 0.13% | 378 | 2 | Town |
| Norris | 7 | 762 | 747 | 0.13% | 404 | 2 | Town |
Easley is the largest city in Pickens County, with a population of 28,302.
Norris is the smallest city in Pickens County, with a population of 762.
There are 7 cities in Pickens County, South Carolina.