| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Spartanburg | 1 | 40,261 | 38,606 | 0.71% | 1,988 | 20 | City |
| Lyman | 2 | 7,296 | 6,140 | 2.72% | 1,076 | 7 | Town |
| Woodruff | 3 | 6,237 | 4,311 | 3.5% | 810 | 8 | City |
| Duncan | 4 | 4,802 | 4,044 | 2.72% | 669 | 7 | Town |
| Wellford | 5 | 4,020 | 3,386 | 2.71% | 756 | 5 | City |
| Inman | 6 | 3,550 | 2,998 | 2.66% | 1,874 | 2 | City |
| Landrum | 7 | 2,942 | 2,480 | 2.69% | 1,034 | 3 | City |
| Pacolet | 8 | 2,715 | 2,285 | 2.69% | 470 | 6 | Town |
| Cowpens | 9 | 2,309 | 2,030 | 2.3% | 1,006 | 2 | Town |
| Reidville | 10 | 1,958 | 1,640 | 2.78% | 1,112 | 2 | Town |
| Chesnee | 11 | 984 | 828 | 2.71% | 919 | 1 | City |
| Campobello | 12 | 803 | 677 | 2.69% | 289 | 3 | Town |
Spartanburg is the largest city in Spartanburg County, with a population of 40,261.
Campobello is the smallest city in Spartanburg County, with a population of 803.
There are 12 cities in Spartanburg County, South Carolina.