Woodruff
- County:
- Spartanburg County
- County Seat:
- No
- Area (mi²):
- 7.704
- State:
- South Carolina
Woodruff is a city located in Spartanburg County, South Carolina. Woodruff has a 2026 population of 5,072. Woodruff is currently growing at a rate of 10.4% annually and its population has increased by 19.71% since the most recent census, which recorded a population of 4,237 in 2020.