5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fort Mill | 1 | 41,764 | 25,204 | 7.08% | 2,145 | 19 | Town |
| Lancaster | 2 | 9,832 | 8,523 | 2.27% | 1,220 | 8 | City |
| Kershaw | 3 | 2,147 | 1,748 | 3.22% | 1,071 | 2 | Town |
| Van Wyck | 4 | 1,116 | 884 | 3.62% | 108 | 10 | Town |
| Heath Springs | 5 | 905 | 746 | 3.08% | 557 | 2 | Town |
Fort Mill is the largest city in Lancaster County, with a population of 41,764.
Heath Springs is the smallest city in Lancaster County, with a population of 905.
There are 5 cities in Lancaster County, South Carolina.