| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fort Mill | 1 | 41,426 | 25,195 | 7.12% | 2,128 | 19 | Town |
| Lancaster | 2 | 9,834 | 8,502 | 2.19% | 1,221 | 8 | City |
| Kershaw | 3 | 2,103 | 1,729 | 3.19% | 1,049 | 2 | Town |
| Van Wyck | 4 | 1,103 | 879 | 3.57% | 106 | 10 | Town |
| Heath Springs | 5 | 885 | 737 | 2.91% | 545 | 2 | Town |
Fort Mill is the largest city in Lancaster County, with a population of 41,426.
Heath Springs is the smallest city in Lancaster County, with a population of 885.
There are 5 cities in Lancaster County, South Carolina.