| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Pine Ridge | 1 | 2,382 | 2,173 | 1.53% | 527 | 5 | Town |
| St. Matthews | 2 | 1,822 | 1,849 | -0.27% | 948 | 2 | Town |
| Cameron | 3 | 366 | 373 | -0.27% | 117 | 3 | Town |
| Woodford | 4 | 155 | 159 | -0.64% | 197 | 1 | Town |
Pine Ridge is the largest city in Calhoun County, with a population of 2,382.
Woodford is the smallest city in Calhoun County, with a population of 155.
There are 4 cities in Calhoun County, South Carolina.