| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Gaffney | 1 | 12,538 | 12,722 | -0.36% | 1,300 | 10 | City |
| Blacksburg | 2 | 1,982 | 1,887 | 0.87% | 1,059 | 2 | Town |
| Central Pacolet | 3 | 253 | 211 | 2.85% | 1,072 | 0 | Town |
Gaffney is the largest city in Cherokee County, with a population of 12,538.
Central Pacolet is the smallest city in Cherokee County, with a population of 253.
There are 3 cities in Cherokee County, South Carolina.