| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Orangeburg | 1 | 13,441 | 13,174 | 0.43% | 1,491 | 9 | City |
| Holly Hill | 2 | 1,272 | 1,313 | -0.63% | 727 | 2 | Town |
| Branchville | 3 | 967 | 987 | -0.41% | 305 | 3 | Town |
| Santee | 4 | 771 | 793 | -0.52% | 308 | 3 | Town |
| Bowman | 5 | 766 | 786 | -0.52% | 651 | 1 | Town |
| North | 6 | 666 | 684 | -0.6% | 771 | 1 | Town |
| Elloree | 7 | 542 | 567 | -0.91% | 510 | 1 | Town |
| Springfield | 8 | 434 | 449 | -0.69% | 250 | 2 | Town |
| Neeses | 9 | 316 | 318 | -0.32% | 185 | 2 | Town |
| Norway | 10 | 274 | 284 | -0.72% | 346 | 1 | Town |
| Eutawville | 11 | 265 | 260 | 0% | 278 | 1 | Town |
| Rowesville | 12 | 246 | 250 | -0.4% | 295 | 1 | Town |
| Cordova | 13 | 136 | 144 | -1.45% | 312 | 0 | Town |
| Livingston | 14 | 128 | 130 | -0.78% | 163 | 1 | Town |
| Vance | 15 | 119 | 123 | -0.83% | 235 | 1 | Town |
| Cope | 16 | 35 | 37 | -2.78% | 140 | 0 | Town |
Orangeburg is the largest city in Orangeburg County, with a population of 13,441.
Cope is the smallest city in Orangeburg County, with a population of 35.
There are 16 cities in Orangeburg County, South Carolina.