
Santee
- County:
- Orangeburg County
- County Seat:
- No
- Area (mi²):
- 2.501
- State:
- South Carolina
Santee is a town located in Orangeburg County, South Carolina. Santee has a 2025 population of 799. Santee is currently declining at a rate of -0.75% annually and its population has decreased by -3.85% since the most recent census, which recorded a population of 831 in 2020.
The average household income in Santee is $60,311 with a poverty rate of 37.78%. The median age in Santee is 51.6 years: 48.7 years for males, and 55.6 years for females.