5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Walterboro | 1 | 5,480 | 5,503 | -0.07% | 772 | 7 | City |
| Cottageville | 2 | 729 | 701 | 0.69% | 213 | 3 | Town |
| Smoaks | 3 | 97 | 99 | 0% | 60 | 2 | Town |
| Williams | 4 | 97 | 97 | 0% | 115 | 1 | Town |
| Lodge | 5 | 82 | 82 | 0% | 26 | 3 | Town |
Walterboro is the largest city in Colleton County, with a population of 5,480.
Lodge is the smallest city in Colleton County, with a population of 82.
There are 5 cities in Colleton County, South Carolina.