10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Florence | 1 | 40,950 | 40,097 | 0.42% | 1,672 | 24.49 | City |
| Lake City | 2 | 5,911 | 6,035 | -0.42% | 1,085 | 5.45 | City |
| Timmonsville | 3 | 2,107 | 2,101 | 0.05% | 759 | 2.78 | Town |
| Johnsonville | 4 | 1,360 | 1,379 | -0.29% | 643 | 2.12 | City |
| Pamplico | 5 | 1,050 | 1,060 | -0.19% | 648 | 1.62 | Town |
| Coward | 6 | 753 | 748 | 0.13% | 213 | 3.53 | Town |
| Scranton | 7 | 656 | 653 | 0.15% | 828 | 0.79 | Town |
| Danwood | 8 | 588 | 361 | 7.3% | 310 | 1.90 | CDP |
| Olanta | 9 | 538 | 547 | -0.37% | 541 | 0.99 | Town |
| Stuckey | 10 | 190 | 197 | -0.52% | 203 | 0.94 | Town |
Florence is the largest city in Florence County, with a population of 40,950.
Stuckey is the smallest city in Florence County.
There are 10 cities in Florence County, South Carolina.