10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fort Mill | 1 | 39,251 | 25,188 | 7.72% | 1,991 | 19.71 | Town |
| Lancaster | 2 | 9,489 | 8,523 | 2.08% | 1,334 | 7.11 | City |
| Springdale | 3 | 2,582 | 2,878 | 0.04% | 611 | 4.22 | CDP |
| Kershaw | 4 | 2,041 | 1,700 | 3.45% | 1,099 | 1.86 | Town |
| Irwin | 5 | 1,984 | 1,308 | 2% | 665 | 2.98 | CDP |
| Van Wyck | 6 | 1,066 | 875 | 3.7% | 103 | 10.37 | Town |
| Heath Springs | 7 | 887 | 749 | 3.26% | 546 | 1.63 | Town |
| Unity | 8 | 791 | 641 | 7.18% | 374 | 2.11 | CDP |
| Buford | 9 | 654 | 708 | 7.21% | 287 | 2.28 | CDP |
| Tradesville | 10 | 84 | 90 | 7.69% | 42 | 2 | CDP |
Fort Mill is the largest city in Lancaster County, with a population of 39,251.
Tradesville is the smallest city in Lancaster County.
There are 10 cities in Lancaster County, South Carolina.