5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fort Mill | 1 | 39,004 | 25,204 | 7.62% | 2,004 | 19 | Town |
| Lancaster | 2 | 9,614 | 8,523 | 2.32% | 1,193 | 8 | City |
| Kershaw | 3 | 2,080 | 1,748 | 3.28% | 1,038 | 2 | Town |
| Van Wyck | 4 | 1,077 | 884 | 3.66% | 104 | 10 | Town |
| Heath Springs | 5 | 878 | 746 | 3.05% | 540 | 2 | Town |
Fort Mill is the largest city in Lancaster County, with a population of 39,004.
Heath Springs is the smallest city in Lancaster County, with a population of 878.
There are 5 cities in Lancaster County, South Carolina.