12 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Spartanburg | 1 | 39,856 | 38,604 | 0.63% | 1,968 | 20 | City |
| Lyman | 2 | 7,122 | 6,205 | 2.64% | 1,051 | 7 | Town |
| Woodruff | 3 | 5,280 | 4,237 | 4.1% | 685 | 8 | City |
| Duncan | 4 | 4,725 | 4,070 | 2.85% | 659 | 7 | Town |
| Wellford | 5 | 3,832 | 3,337 | 2.65% | 721 | 5 | City |
| Inman | 6 | 3,442 | 3,000 | 2.62% | 1,817 | 2 | City |
| Landrum | 7 | 2,867 | 2,491 | 2.69% | 1,007 | 3 | City |
| Pacolet | 8 | 2,635 | 2,288 | 2.69% | 456 | 6 | Town |
| Cowpens | 9 | 2,279 | 2,032 | 2.2% | 993 | 2 | Town |
| Reidville | 10 | 1,892 | 1,640 | 2.71% | 1,074 | 2 | Town |
| Chesnee | 11 | 960 | 833 | 2.67% | 896 | 1 | City |
| Campobello | 12 | 786 | 685 | 2.61% | 283 | 3 | Town |
Spartanburg is the largest city in Spartanburg County, with a population of 39,856.
Campobello is the smallest city in Spartanburg County, with a population of 786.
There are 12 cities in Spartanburg County, South Carolina.