36 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Spartanburg | 1 | 39,328 | 38,608 | 0.37% | 1,942 | 20 | City |
| Boiling Springs | 2 | 11,934 | 9,953 | 2.12% | 1,746 | 7 | CDP |
| Valley Falls | 3 | 7,305 | 7,269 | 0.93% | 1,408 | 5 | CDP |
| Lyman | 4 | 7,044 | 6,206 | 2.44% | 1,063 | 7 | Town |
| Woodruff | 5 | 4,797 | 4,227 | 2.43% | 945 | 5 | City |
| Duncan | 6 | 4,675 | 4,065 | 2.68% | 746 | 6 | Town |
| Whitney | 7 | 4,668 | 3,999 | 7.16% | 1,530 | 3 | CDP |
| Saxon | 8 | 4,358 | 3,727 | 1.44% | 1,830 | 2 | CDP |
| Roebuck | 9 | 4,246 | 2,768 | 3.31% | 989 | 4 | CDP |
| Hilltop | 10 | 4,066 | 3,483 | 7.14% | 2,228 | 2 | CDP |
| Southern Shops | 11 | 3,878 | 3,965 | 0.18% | 1,088 | 4 | CDP |
| Wellford | 12 | 3,809 | 3,354 | 2.45% | 832 | 5 | City |
| Inman | 13 | 3,410 | 3,007 | 2.43% | 1,944 | 2 | City |
| Arkwright | 14 | 3,236 | 2,493 | 7.15% | 1,252 | 3 | CDP |
| Arcadia | 15 | 2,899 | 2,991 | 0.62% | 1,479 | 2 | CDP |
| Landrum | 16 | 2,834 | 2,491 | 2.5% | 1,071 | 3 | City |
| Ben Avon | 17 | 2,701 | 2,189 | 7.14% | 1,616 | 2 | CDP |
| Pacolet | 18 | 2,603 | 2,288 | 2.48% | 450 | 6 | Town |
| Cowpens | 19 | 2,298 | 2,027 | 2.41% | 1,001 | 2 | Town |
| Camp Croft | 20 | 2,116 | 1,991 | 7.14% | 799 | 3 | CDP |
| Mayo | 21 | 2,008 | 1,770 | 1.41% | 660 | 3 | CDP |
| Reidville | 22 | 1,878 | 1,645 | 2.57% | 1,066 | 2 | Town |
| Fairforest | 23 | 1,609 | 1,484 | -0.37% | 769 | 2 | CDP |
| Drayton | 24 | 1,264 | 1,097 | 7.12% | 902 | 1 | CDP |
| Clifton | 25 | 1,067 | 691 | 3.39% | 994 | 1 | CDP |
| Chesnee | 26 | 949 | 838 | 2.37% | 886 | 1 | City |
| Inman Mills | 27 | 932 | 801 | -0.85% | 864 | 1 | CDP |
| Campobello | 28 | 776 | 681 | 2.51% | 279 | 3 | Town |
| Startex | 29 | 476 | 556 | -5.18% | 430 | 1 | CDP |
| Enoree | 30 | 385 | 560 | -4.7% | 249 | 2 | CDP |
| Pauline | 31 | 286 | 204 | 7.12% | 200 | 1 | CDP |
| Glendale | 32 | 241 | 312 | -1.63% | 1,137 | 0 | CDP |
| Glenn Springs | 33 | 234 | 231 | 7.34% | 106 | 2 | CDP |
| Converse | 34 | 149 | 545 | -17.22% | 216 | 1 | CDP |
| Gramling | 35 | 99 | 97 | 7.61% | 99 | 1 | CDP |
| Fingerville | 36 | 90 | 31 | -3.23% | 369 | 0 | CDP |
Spartanburg is the largest city in Spartanburg County, with a population of 39,328.
Fingerville is the smallest city in Spartanburg County, with a population of 90.
There are 36 cities in Spartanburg County, South Carolina.