12 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Spartanburg | 1 | 40,107 | 38,604 | 0.63% | 1,980 | 20 | City |
| Lyman | 2 | 7,306 | 6,205 | 2.58% | 1,078 | 7 | Town |
| Woodruff | 3 | 5,489 | 4,237 | 3.96% | 712 | 8 | City |
| Duncan | 4 | 4,856 | 4,070 | 2.77% | 677 | 7 | Town |
| Wellford | 5 | 3,931 | 3,337 | 2.58% | 740 | 5 | City |
| Inman | 6 | 3,531 | 3,000 | 2.59% | 1,864 | 2 | City |
| Landrum | 7 | 2,942 | 2,491 | 2.62% | 1,034 | 3 | City |
| Pacolet | 8 | 2,705 | 2,288 | 2.66% | 468 | 6 | Town |
| Cowpens | 9 | 2,329 | 2,032 | 2.19% | 1,015 | 2 | Town |
| Reidville | 10 | 1,943 | 1,640 | 2.7% | 1,103 | 2 | Town |
| Chesnee | 11 | 986 | 833 | 2.71% | 921 | 1 | City |
| Campobello | 12 | 806 | 685 | 2.54% | 290 | 3 | Town |
Spartanburg is the largest city in Spartanburg County, with a population of 40,107.
Campobello is the smallest city in Spartanburg County, with a population of 806.
There are 12 cities in Spartanburg County, South Carolina.