8 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jacksonville | 1 | 14,943 | 14,030 | 1.03% | 987 | 15 | City |
| Rusk | 2 | 5,629 | 5,400 | 0.68% | 778 | 7 | City |
| Alto | 3 | 1,082 | 1,028 | 0.84% | 635 | 2 | Town |
| New Summerfield | 4 | 939 | 840 | 1.84% | 200 | 5 | City |
| Wells | 5 | 926 | 856 | 1.31% | 484 | 2 | Town |
| Gallatin | 6 | 352 | 321 | 1.44% | 76 | 5 | City |
| Reklaw | 7 | 351 | 333 | 0.86% | 119 | 3 | City |
| Cuney | 8 | 119 | 113 | 0.85% | 72 | 2 | Town |
Jacksonville is the largest city in Cherokee County, with a population of 14,943.
Cuney is the smallest city in Cherokee County, with a population of 119.
There are 8 cities in Cherokee County, Texas.