8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jacksonville | 1 | 14,791 | 14,030 | 1.04% | 976 | 15 | City |
| Rusk | 2 | 5,591 | 5,400 | 0.68% | 773 | 7 | City |
| Alto | 3 | 1,073 | 1,028 | 0.85% | 629 | 2 | Town |
| New Summerfield | 4 | 922 | 840 | 1.77% | 196 | 5 | City |
| Wells | 5 | 914 | 856 | 1.22% | 477 | 2 | Town |
| Reklaw | 6 | 348 | 333 | 0.87% | 118 | 3 | City |
| Gallatin | 7 | 347 | 321 | 1.46% | 75 | 5 | City |
| Cuney | 8 | 118 | 113 | 0.85% | 72 | 2 | Town |
Jacksonville is the largest city in Cherokee County, with a population of 14,791.
Cuney is the smallest city in Cherokee County, with a population of 118.
There are 8 cities in Cherokee County, Texas.