| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jacksonville | 1 | 14,817 | 14,025 | 1.08% | 978 | 15 | City |
| Rusk | 2 | 5,603 | 5,407 | 0.63% | 775 | 7 | City |
| Alto | 3 | 1,072 | 1,026 | 0.85% | 629 | 2 | Town |
| New Summerfield | 4 | 931 | 834 | 1.75% | 198 | 5 | City |
| Wells | 5 | 902 | 857 | 1.01% | 471 | 2 | Town |
| Reklaw | 6 | 352 | 335 | 0.86% | 120 | 3 | City |
| Gallatin | 7 | 349 | 322 | 1.45% | 76 | 5 | City |
| Cuney | 8 | 120 | 113 | 0.84% | 73 | 2 | Town |
Jacksonville is the largest city in Cherokee County, with a population of 14,817.
Cuney is the smallest city in Cherokee County, with a population of 120.
There are 8 cities in Cherokee County, Texas.