| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Hondo | 1 | 9,275 | 8,409 | 1.59% | 923 | 10 | City |
| Devine | 2 | 4,722 | 4,308 | 1.5% | 1,469 | 3 | City |
| Castroville | 3 | 3,499 | 2,972 | 1.6% | 978 | 4 | City |
| Natalia | 4 | 1,410 | 1,201 | 2.69% | 1,014 | 1 | City |
Hondo is the largest city in Medina County, with a population of 9,275.
Natalia is the smallest city in Medina County, with a population of 1,410.
There are 4 cities in Medina County, Texas.