4 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Hondo | 1 | 9,245 | 8,416 | 1.52% | 920 | 10 | City |
| Devine | 2 | 4,765 | 4,335 | 1.53% | 1,483 | 3 | City |
| Castroville | 3 | 3,313 | 2,976 | 1.72% | 926 | 4 | City |
| Natalia | 4 | 1,432 | 1,203 | 2.73% | 1,029 | 1 | City |
Hondo is the largest city in Medina County, with a population of 9,245.
Natalia is the smallest city in Medina County, with a population of 1,432.
There are 4 cities in Medina County, Texas.