7 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Woodville | 1 | 2,350 | 2,335 | 0.13% | 747 | 3 | Town |
| Woodville | 2 | 2,350 | 2,334 | 0.13% | 747 | 3 | Town |
| Warren | 3 | 725 | 973 | -0.28% | 172 | 4 | CDP |
| Colmesneil | 4 | 556 | 538 | 0.54% | 278 | 2 | City |
| Colmesneil | 5 | 556 | 538 | 0.54% | 278 | 2 | City |
| Chester | 6 | 273 | 271 | 0% | 173 | 2 | Town |
| Chester | 7 | 273 | 271 | 0% | 173 | 2 | Town |
Woodville is the largest city in Tyler County, with a population of 2,350.
Chester is the smallest city in Tyler County, with a population of 273.
There are 7 cities in Tyler County, Texas.