6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Big Stone Gap | 1 | 5,048 | 5,243 | -0.77% | 1,052 | 5 | Town |
| Wise | 2 | 2,843 | 2,972 | -0.91% | 936 | 3 | Town |
| Coeburn | 3 | 1,543 | 1,607 | -0.84% | 791 | 2 | Town |
| Appalachia | 4 | 1,361 | 1,436 | -1.09% | 395 | 3 | Town |
| Pound | 5 | 832 | 870 | -0.95% | 319 | 3 | Town |
| St. Paul | 6 | 828 | 862 | -0.84% | 601 | 1 | Town |
Big Stone Gap is the largest city in Wise County, with a population of 5,048.
St. Paul is the smallest city in Wise County, with a population of 828.
There are 6 cities in Wise County, Virginia.