6 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Big Stone Gap | 1 | 5,009 | 5,243 | -0.77% | 1,044 | 5 | Town |
| Wise | 2 | 2,817 | 2,972 | -0.91% | 927 | 3 | Town |
| Coeburn | 3 | 1,530 | 1,607 | -0.84% | 785 | 2 | Town |
| Appalachia | 4 | 1,346 | 1,436 | -1.1% | 391 | 3 | Town |
| Pound | 5 | 825 | 870 | -0.84% | 317 | 3 | Town |
| St. Paul | 6 | 821 | 862 | -0.85% | 596 | 1 | Town |
Big Stone Gap is the largest city in Wise County, with a population of 5,009.
St. Paul is the smallest city in Wise County, with a population of 821.
There are 6 cities in Wise County, Virginia.