11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Big Stone Gap | 1 | 5,027 | 5,244 | -0.85% | 1,048 | 5 | Town |
| Wise | 2 | 2,831 | 2,978 | -1.01% | 932 | 3 | Town |
| Coeburn | 3 | 1,536 | 1,601 | -0.84% | 788 | 2 | Town |
| Appalachia | 4 | 1,355 | 1,434 | -1.17% | 394 | 3 | Town |
| East Stone Gap | 5 | 1,035 | 858 | 7.14% | 1,927 | 1 | CDP |
| Pound | 6 | 828 | 868 | -0.96% | 318 | 3 | Town |
| St. Paul | 7 | 821 | 863 | -0.97% | 596 | 1 | Town |
| The University Virginia's College Wise | 8 | 812 | 684 | 7.12% | 1,888 | 0 | CDP |
| Stonega | 9 | 188 | 206 | 7.43% | 302 | 1 | CDP |
| Osaka | 10 | 128 | 74 | 7.56% | 297 | 0 | CDP |
| Dunbar | 11 | 54 | 96 | 8% | 2,348 | 0 | CDP |
Big Stone Gap is the largest city in Wise County, with a population of 5,027.
Dunbar is the smallest city in Wise County, with a population of 54.
There are 11 cities in Wise County, Virginia.