Gaylesville
- County:
- Cherokee County
- County Seat:
- No
- Area (mi²):
- 1.387
- State:
- Alabama
Gaylesville is a town located in Cherokee County, Alabama. Gaylesville has a 2026 population of 177. Gaylesville is currently growing at a rate of 1.72% annually and its population has increased by 3.51% since the most recent census, which recorded a population of 171 in 2020.