Opelika
- County:
- Lee County
- County Seat:
- Yes
- Area (mi²):
- 62.014
- State:
- Alabama
Opelika is a city located in Lee County, Alabama. Opelika has a 2026 population of 35,005. It is also the county seat of Lee County. Opelika is currently growing at a rate of 3.9% annually and its population has increased by 12.66% since the most recent census, which recorded a population of 31,071 in 2020.