San Luis
- County:
- Yuma County
- County Seat:
- No
- Area (mi²):
- 33.822
- State:
- Arizona
San Luis is a city located in Yuma County, Arizona. San Luis has a 2026 population of 40,064. San Luis is currently growing at a rate of 3.98% annually and its population has increased by 12% since the most recent census, which recorded a population of 35,771 in 2020.