De Soto is a city located in Missouri. With a 2020 population of 6,333, it is the 111th largest city in Missouri and the 4177th largest city in the United States. De Soto is currently declining at a rate of -0.20% annually and its population has decreased by -1.05% since the most recent census, which recorded a population of 6,400 in 2010. De Soto reached it's highest population of 6,426 in 2011. Spanning over 4 miles, De Soto has a population density of 1,445 people per square mile.
The average household income in De Soto is $48,753 with a poverty rate of 21.18%. The median rental costs in recent years comes to $719 per month, and the median house value is $108,500. The median age in De Soto is 37.7 years, 35.4 years for males, and 39 years for females. For every 100 females there are 83.2 males.