Port St. Lucie
- County:
- St. Lucie County
- County Seat:
- No
- Area (mi²):
- 119.216
- State:
- Florida
Port St. Lucie is a city located in St. Lucie County, Florida. Port St. Lucie has a 2026 population of 258,575. Port St. Lucie is currently growing at a rate of 4.82% annually and its population has increased by 25.02% since the most recent census, which recorded a population of 206,828 in 2020.