Brussels
- County:
- Calhoun County
- County Seat:
- No
- Area (mi²):
- 0.56
- State:
- Illinois
Brussels is a village located in Calhoun County, Illinois. Brussels has a 2026 population of 115. Brussels is currently declining at a rate of -1.71% annually and its population has decreased by -4.96% since the most recent census, which recorded a population of 121 in 2020.