
Murphysboro
- County:
- Jackson County
- County Seat:
- Yes
- Area (mi²):
- 5.248
- State:
- Illinois
Murphysboro is a city located in Jackson County, Illinois. Murphysboro has a 2025 population of 6,883. It is also the county seat of Jackson County. Murphysboro is currently declining at a rate of -0.58% annually and its population has decreased by -2.81% since the most recent census, which recorded a population of 7,082 in 2020.
The average household income in Murphysboro is $57,011 with a poverty rate of 16.4%. The median age in Murphysboro is 40 years: 42.1 years for males, and 37 years for females.