Guthrie Center
- County:
- Guthrie County
- County Seat:
- Yes
- Area (mi²):
- 2.379
- State:
- Iowa
Guthrie Center is a city located in Guthrie County, Iowa. Guthrie Center has a 2026 population of 1,579. It is also the county seat of Guthrie County. Guthrie Center is currently declining at a rate of -0.5% annually and its population has decreased by -0.25% since the most recent census, which recorded a population of 1,583 in 2020.