St. Francis
- County:
- Cheyenne County
- County Seat:
- Yes
- Area (mi²):
- 0.857
- State:
- Kansas
St. Francis is a city located in Cheyenne County, Kansas. St. Francis has a 2026 population of 1,282. It is also the county seat of Cheyenne County. St. Francis is currently growing at a rate of 0.47% annually and its population has increased by 1.1% since the most recent census, which recorded a population of 1,268 in 2020.